The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery.

ABSTRACT: Motivation:As cancer genomics initiatives move toward comprehensive identification of genetic alterations in cancer, attention is now turning to understanding how interactions among these genes lead to the acquisition of tumor hallmarks. Emerging pharmacological and clinical data suggest a highly promising role of cancer-specific protein-protein interactions (PPIs) as druggable cancer targets. However, large-scale experimental identification of cancer-related PPIs remains challenging, and currently available resources to explore oncogenic PPI networks are limited. Results:Recently, we have developed a PPI high-throughput screening platform to detect PPIs between cancer-associated proteins in the context of cancer cells. Here, we present the OncoPPi Portal, an interactive web resource that

SUBMITTER: Ivanov AA 

PROVIDER: S-EPMC6030952 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature