Carriage of Cronobacter sakazakii in the Very Preterm Infant Gut.

ABSTRACT:

Background

Cronobacter sakazakii causes severe neonatal infections, but we know little about gut carriage of this pathogen in very low birthweight infants.

Methods

We sequenced 16S ribosomal RNA (rRNA) genes from 2304 stools from 121 children at St Louis Children's Hospital whose birthweight was ≤1500 g, attempted to isolate C. sakazakii from 157 of these stools, genome-sequenced the recovered isolates, and sought correlations between indices of Cronobacter excretion, host characteristics, and unit formula use.

Results

Of these 2304 stools, 1271 (55.2%) contained Cronobacter rRNA gene sequences. The median (interquartile range) per-subject percentage of specimens with at least 1 Cronobacter sequence and the median per-subject read density were 57.1 (25.5-87.3) and 0.0

SUBMITTER: Chandrasekaran S 

PROVIDER: S-EPMC6030953 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature