Placental Weight and Risk of Cryptorchidism and Hypospadias in the Collaborative Perinatal Project.

ABSTRACT: Cryptorchidism and hypospadias are the most common congenital anomalies of the genitourinary tract in males, but their etiology remains unclear. Placental insufficiency has been suggested to be linked to both conditions. Placental weight is a commonly used proxy measure for placental insufficiency; thus, we examined placental weight and other placental characteristics in relation to cryptorchidism and hypospadias in the Collaborative Perinatal Project, a US mother-child cohort study. Pregnant women were recruited between 1959 and 1965. The analysis contrasted boys with cryptorchidism (n = 413) and boys with hypospadias (n = 145) with boys without cryptorchidism (n = 23,799) and boys without hypospadias (n = 22,326). Odds ratios and 95% confidence intervals were calculated using uncondition

SUBMITTER: Ghazarian AA 

PROVIDER: S-EPMC6030958 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature