GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models.

ABSTRACT: Due to the involvement of G protein-coupled receptors (GPCRs) in most of the physiological and pathological processes in humans they have been attracting a lot of attention from pharmaceutical industry as well as from scientific community. Therefore, the need for new, high quality structures of GPCRs is enormous. The updated homology modeling service GPCRM (http://gpcrm.biomodellab.eu/) meets those expectations by greatly reducing the execution time of submissions (from days to hours/minutes) with nearly the same average quality of obtained models. Additionally, due to three different scoring functions (Rosetta, Rosetta-MP, BCL::Score) it is possible to select accurate models for the required purposes: the structure of the binding site, the transmembrane domain or the overall shape of the

SUBMITTER: Miszta P 

PROVIDER: S-EPMC6030973 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature