InterEvDock2: an expanded server for protein docking using evolutionary and biological information from homology models and multimeric inputs.

ABSTRACT: Computational protein docking is a powerful strategy to predict structures of protein-protein interactions and provides crucial insights for the functional characterization of macromolecular cross-talks. We previously developed InterEvDock, a server for ab initio protein docking based on rigid-body sampling followed by consensus scoring using physics-based and statistical potentials, including the InterEvScore function specifically developed to incorporate co-evolutionary information in docking. InterEvDock2 is a major evolution of InterEvDock which allows users to submit input sequences - not only structures - and multimeric inputs and to specify constraints for the pairwise docking process based on previous knowledge about the interaction. For this purpose, we added modules in InterEvDoc

SUBMITTER: Quignot C 

PROVIDER: S-EPMC6030979 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature