CalFitter: a web server for analysis of protein thermal denaturation data.

ABSTRACT: Despite significant advances in the understanding of protein structure-function relationships, revealing protein folding pathways still poses a challenge due to a limited number of relevant experimental tools. Widely-used experimental techniques, such as calorimetry or spectroscopy, critically depend on a proper data analysis. Currently, there are only separate data analysis tools available for each type of experiment with a limited model selection. To address this problem, we have developed the CalFitter web server to be a unified platform for comprehensive data fitting and analysis of protein thermal denaturation data. The server allows simultaneous global data fitting using any combination of input data types and offers 12 protein unfolding pathway models for selection, including irreve

SUBMITTER: Mazurenko S 

PROVIDER: S-EPMC6031030 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature