BRepertoire: a user-friendly web server for analysing antibody repertoire data.

ABSTRACT: Antibody repertoire analysis by high throughput sequencing is now widely used, but a persisting challenge is enabling immunologists to explore their data to discover discriminating repertoire features for their own particular investigations. Computational methods are necessary for large-scale evaluation of antibody properties. We have developed BRepertoire, a suite of user-friendly web-based software tools for large-scale statistical analyses of repertoire data. The software is able to use data preprocessed by IMGT, and performs statistical and comparative analyses with versatile plotting options. BRepertoire has been designed to operate in various modes, for example analysing sequence-specific V(D)J gene usage, discerning physico-chemical properties of the CDR regions and clustering of cl

SUBMITTER: Margreitter C 

PROVIDER: S-EPMC6031031 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature