MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action.

ABSTRACT: Summary:Chemical-genomic approaches that map interactions between small molecules and genetic perturbations offer a promising strategy for functional annotation of uncharacterized bioactive compounds. We recently developed a new high-throughput platform for mapping chemical-genetic (CG) interactions in yeast that can be scaled to screen large compound collections, and we applied this system to generate CG interaction profiles for more than 13 000 compounds. When integrated with the existing global yeast genetic interaction network, CG interaction profiles can enable mode-of-action prediction for previously uncharacterized compounds as well as discover unexpected secondary effects for known drugs. To facilitate future analysis of these valuable data, we developed a public database and web i

SUBMITTER: Nelson J 

PROVIDER: S-EPMC6031042 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature