Early nonreactivity in the conjunctival provocation test predicts beneficial outcome of sublingual immunotherapy.

ABSTRACT:

Background

Clinical practice needs a common parameter that can provide an early, reliable estimation of the outcome of sublingual immunotherapy (SLIT) in an upcoming pollen season. We investigated whether the conjunctival provocation test (CPT) can predict the beneficial outcome of SLIT in patients with allergic rhinoconjunctivitis after 4 weeks of treatment.

Methods

We conducted two separate prospective, randomized, double-blind, placebo-controlled, multicenter trials. Adults 18-75 years of age received placebo or SLIT tablets containing tree or grass pollen allergoids and underwent CPTs. Participants receiving SLIT were divided into two groups (reactive, nonreactive) according to their CPT reactions after 4 weeks of treatment. These two groups were compared with regard to

SUBMITTER: Kother J 

PROVIDER: S-EPMC6031191 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature