Prediction of co-regulated genes in Bacillus subtilis on the basis of upstream elements conserved across three closely related species.

ABSTRACT:

Background

Identification of co-regulated genes is essential for elucidating transcriptional regulatory networks and the function of uncharacterized genes. Although co-regulated genes should have at least one common sequence element, it is generally difficult to identify these genes from the presence of this element because it is very easily obscured by noise. To overcome this problem, we used conserved information from three closely related species: Bacillus subtilis, B. halodurans and B. stearothermophilus.

Results

Even though such species have a limited number of clearly orthologous genes, we obtained 1,884 phylogenetically conserved elements from the upstream intergenic regions of 1,568 B. subtilis genes. Similarity between these elements was used to cluster these genes.

SUBMITTER: Terai G 

PROVIDER: S-EPMC60312 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature