Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care.

ABSTRACT:

Objective

To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin.

Design

Prospective open cohort study.

Setting

UK general practices contributing to QResearch or Clinical Practice Research Datalink.

Participants

132 231 warfarin, 7744 dabigatran, 37 863 rivaroxaban, and 18 223 apixaban users without anticoagulant prescriptions for 12 months before study entry, subgrouped into 103 270 patients with atrial fibrillation and 92 791 without atrial fibrillation between 2011 and 2016.

Main outcome measures

Major bleeding leading to hospital admission or death. Specific sites of bleeding and all cause mortality were also studied.

SUBMITTER: Vinogradova Y 

PROVIDER: S-EPMC6031213 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature