The somatic mutation landscape of premalignant colorectal adenoma.

ABSTRACT:

Objective

There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma.

Design

Whole-exome sequencing and targeted sequencing were carried out in 149 adenoma samples and paired blood from patients with conventional adenoma or sessile serrated adenoma to characterise the somatic mutation landscape for premalignant colorectal lesions. The identified somatic mutations were compared with those in colorectal cancer (CRC) samples from The Cancer Genome Atlas. A supervised random forest model was employed to identify gene panels differentiating adenoma from CRC.

Results

Similar soma

SUBMITTER: Lin SH 

PROVIDER: S-EPMC6031265 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature