Differential preventive activity of sulindac and atorvastatin in Apc^+/Min-FCCCmice with or without colorectal adenomas.

ABSTRACT:

Objective

The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc^+/Min-FCCC mice with known tumour-bearing status at treatment initiation.

Design

Male mice (6-8 weeks old) underwent colonoscopy and received control chow or chow with sulindac (300 ppm), atorvastatin (100 ppm) or sulindac/atorvastatin. Tissues were collected from mice treated for 14 weeks (histopathology) or 7 days (gene expression). Cell cycle analyses were performed on SW480 colon carcinoma cells treated with sulindac, atorvastatin or both.

Results

The multiplicity of

SUBMITTER: Chang WL 

PROVIDER: S-EPMC6031273 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature