Features of <i>GBA</i>-associated Parkinson's disease at presentation in the UK <i>Tracking Parkinson's</i> study.

ABSTRACT:

Objectives

To examine the influence of the glucocerebrosidase (GBA) mutation carrier state on age at onset of Parkinson's disease (PD), the motor phenotype and cognitive function at baseline assessment in a large cohort of UK patients. We also analysed the prevalence of mood and behavioural problems that may confound the assessment of cognitive function.

Methods

We prospectively recruited patients with PD in the Tracking Parkinson's study. We fully sequenced the GBA gene in all recently diagnosed patients (≤3.5 years). We examined cognitive (Montreal Cognitive Assessment) and motor (Movement Disorder Society Unified Parkinson's Disease Rating Scale part 3) function at a baseline assessment, at an average of 1.3 years after diagnosis. We used logistic reg

SUBMITTER: Malek N 

PROVIDER: S-EPMC6031283 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature