Hobbit regulates intracellular trafficking to drive insulin-dependent growth during Drosophila development.

ABSTRACT: All animals must coordinate growth rate and timing of maturation to reach the appropriate final size. Here, we describe hobbit, a novel and conserved gene identified in a forward genetic screen for Drosophila animals with small body size. hobbit is highly conserved throughout eukaryotes, but its function remains unknown. We demonstrate that hobbit mutant animals have systemic growth defects because they fail to secrete insulin. Other regulated secretion events also fail in hobbit mutant animals, including mucin-like 'glue' protein secretion from the larval salivary glands. hobbit mutant salivary glands produce glue-containing secretory granules that are reduced in size. Importantly, secretory granules in hobbit mutant cells lack essential me

SUBMITTER: Neuman SD 

PROVIDER: S-EPMC6031322 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature