Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull.

ABSTRACT: The bones of the cranial vault are formed directly from mesenchymal cells through intramembranous ossification rather than via a cartilage intermediate. Formation and growth of the skull bones involves the interaction of multiple cell-cell signaling pathways, with fibroblast growth factors (FGFs) and their receptors exerting a prominent influence. Mutations within the FGF signaling pathway are the most frequent cause of craniosynostosis, which is a common human craniofacial developmental abnormality characterized by the premature fusion of the cranial sutures. Here, we have developed new mouse models to investigate how different levels of increased FGF signaling can affect the formation of the calvarial bones and associated sutures. Whereas moderate Fgf8 overexpression resulted in d

SUBMITTER: Schmidt L 

PROVIDER: S-EPMC6031357 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature