The effects of acetaldehyde exposure on histone modifications and chromatin structure in human lung bronchial epithelial cells.

ABSTRACT: As the primary metabolite of alcohol and the most abundant carcinogen in tobacco smoke, acetaldehyde is linked to a number of human diseases associated with chronic alcohol consumption and smoking including cancers. In addition to direct DNA damage as a result of the formation of acetaldehyde-DNA adducts, acetaldehyde may also indirectly impact proper genome function through the formation of protein adducts. Histone proteins are the major component of the chromatin. Post-translational histone modifications (PTMs) are critically important for the maintenance of genetic and epigenetic stability. However, little is known about how acetaldehyde-histone adducts affect histone modifications and chromatin structure. The results of protein carbonyl assays suggest that acetaldehyde forms adducts wi

SUBMITTER: Chen D 

PROVIDER: S-EPMC6031465 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature