Hemostasis biomarkers and incident cognitive impairment: the REGARDS study.

ABSTRACT: Essentials Cognitive disorders are increasing and vascular risk factors play a role in this. We performed a nested case control study of hemostasis biomarkers and cognitive impairment (CI). Higher baseline fibrinogen, factor VIII and D-dimer were related to incident CI over 3.5 years. Adjusted for other risk factors, 2+ abnormal markers (but not single ones) led to higher risk.

Summary

Background Vascular risk factors are associated with cognitive impairment, a condition that imposes a substantial public health burden. We hypothesized that hemostasis biomarkers related to vascular disease would be associated with the risk of incident cognitive impairment. Methods We performed a nested case-control study including 1082 participants with 3.5 years of follow-up in the Reasons for Geogr

SUBMITTER: Gillett SR 

PROVIDER: S-EPMC6031469 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature