Ictal and preictal power changes outside of the seizure focus correlate with seizure generalization.

ABSTRACT:

Objective

The treatment of focal epilepsies is largely predicated on the concept that there is a "focus" from which the seizure emanates. Yet, the physiological context that determines if and how ictal activity starts and propagates remains poorly understood. To delineate these phenomena more completely, we studied activity outside the seizure-onset zone prior to and during seizure initiation.

Methods

Stereotactic depth electrodes were implanted in 17 patients with longstanding pharmacoresistant epilepsy for lateralization and localization of the seizure-onset zone. Only seizures with focal onset in mesial temporal structures were used for analysis. Spectral analyses were used to quantify changes in delta, theta, alpha, beta, gamma, and high gamma frequency power, in regions

SUBMITTER: Naftulin JS 

PROVIDER: S-EPMC6031475 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature