Ontology highlight
ABSTRACT:
SUBMITTER: Kaur G
PROVIDER: S-EPMC6031611 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kaur Gundeep G Kaundal Soni S Kapoor Srajan S Grimes Jonathan M JM Huiskonen Juha T JT Thakur Krishan Gopal KG
Scientific reports 20180704 1
CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex. Available crystal structures have captured two distinct, monomeric and domain-swapped homodimeric, oligomeric states of CarD. However, the actual oligomeric state of CarD in solution and its biological relevance has remained unclear. Here, we confirm the presence of the homodimeric state of CarD in sol ...[more]