Assessment of the key regulatory genes and their Interologs for Turner Syndrome employing network approach.

ABSTRACT: Turner Syndrome (TS) is a condition where several genes are affected but the molecular mechanism remains unknown. Identifying the genes that regulate the TS network is one of the main challenges in understanding its aetiology. Here, we studied the regulatory network from manually curated genes reported in the literature and identified essential proteins involved in TS. The power-law distribution analysis showed that TS network carries scale-free hierarchical fractal attributes. This organization of the network maintained the self-ruled constitution of nodes at various levels without having centrality-lethality control systems. Out of twenty-seven genes culminating into leading hubs in the network, we identified two key regulators (KRs) i.e. KDM6A and BDNF. These KRs serve as the backbone f

SUBMITTER: Farooqui A 

PROVIDER: S-EPMC6031616 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature