Dosage compensation and DNA methylation landscape of the X chromosome in mouse liver.

ABSTRACT: DNA methylation plays a key role in X-chromosome inactivation (XCI), a process that achieves dosage compensation for X-encoded gene products between mammalian female and male cells. However, differential sex chromosome dosage complicates genome-wide epigenomic assessments, and the X chromosome is frequently excluded from female-to-male comparative analyses. Using the X chromosome in the sexually dimorphic mouse liver as a model, we provide a general framework for comparing base-resolution DNA methylation patterns across samples that have different chromosome numbers and ask at a systematic level if predictions by historical analyses of X-linked DNA methylation hold true at a base-resolution chromosome-wide level. We demonstrate that sex-specific methylation patterns on the X chromosome lar

SUBMITTER: Duncan CG 

PROVIDER: S-EPMC6031675 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature