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Detection of a 4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 Using Mismatch PCR-RFLP and Its Association with Susceptibility to Breast Cancer

ABSTRACT: It has been shown that a 4-bp insertion/deletion (ins/del) polymorphism of EGLN2 influences the risk of several

SUBMITTER: Hashemi M 

PROVIDER: S-EPMC6031807 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Detection of a 4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 Using Mismatch PCR-RFLP and Its Association with Susceptibility to Breast Cancer

Hashemi Mohammad M   Danesh Hiva H   Bizhani Fatemeh F   Sattarifard Hedieh H   Hashemi Seyed Mehdi SM   Bahari Gholamreza G  

Asian Pacific journal of cancer prevention : APJCP 20180425 4

It has been shown that a 4-bp insertion/deletion (ins/del) polymorphism of EGLN2 influences the risk of several cancers. However, to date, no study has inspected the impact of the 4-bp ins/del polymorphism on breast cancer (BC) risk. A case-control study, including 134 breast cancer patients and 154 healthy women, was here conducted to examine the possible association between EGLN2 4-bp ins/del polymorphism and BC risk in a southeast Iranian population. A mismatched polymerase chain reaction-res  ...[more]