Sequence Analysis of Drug Target Genes with Suicidal Behavior in Bipolar Disorder Patients.

ABSTRACT:

Background

A number of genes have been implicated in recent genome-wide association studies of suicide attempt in bipolar disorder. More focused investigation of genes coding for protein targets of existing drugs may lead to drug repurposing for the treatment and/or prevention of suicide.

Methods

We analyzed 2,457 DNA variants across 197 genes of interest to GlaxoSmithKline across the pipeline in our sample of European patients suffering from bipolar disorder (N = 219). We analyzed these variants for a possible association with the suicide severity score (ranging from suicidal ideation/plan to serious suicide attempt) from the Schedule for Clinical Assessment in Neuropsychiatry. We conducted tests of individual variants and gene-based tests.

Results

We found a

SUBMITTER: Zai CC 

PROVIDER: S-EPMC6032032 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature