Multiregional gene expression profiling identifies MRPS6 as a possible candidate gene for Parkinson's disease.

ABSTRACT: Combining large-scale gene expression approaches and bioinformatics may provide insights into the molecular variability of biological processes underlying neurodegeneration. To identify novel candidate genes and mechanisms, we conducted a multiregional gene expression analysis in postmortem brain. Gene arrays were performed utilizing Affymetrix HG U133 Plus 2.0 gene chips. Brain specimens from 21 different brain regions were taken from Parkinson's disease (PD) (n = 22) and normal aged (n = 23) brain donors. The rationale for conducting a multiregional survey of gene expression changes was based on the assumption that if a gene is changed in more than one brain region, it may be a higher probability candidate gene compared to genes that are changed in a single region. Although no gene was s

SUBMITTER: Papapetropoulos S 

PROVIDER: S-EPMC6032441 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature