Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model.

ABSTRACT:

Background

Primary cytoreductive surgery followed by adjuvant chemotherapy is the standard treatment for advanced epithelial ovarian cancer. The average interval between surgery and chemotherapy initiation is approximately 4-weeks at most centers; however, since surgery may accelerate residual tumor growth, a shorter interval may be more beneficial.

Methods

The murine ID8 cell model of ovarian cancer was used to examine the efficacy of cisplatin treatment administered perioperatively or 7 days after surgical wounding. Luciferase-expressing cells ID8 cells were injected intraperitoneally (i.p.) into female C57/Bl6 mice. Fourteen days post-injection, animals received an abdominal incision or anesthesia alone and received i.p. cisplatin either on the surgical day or 7 days late

SUBMITTER: Lee Y 

PROVIDER: S-EPMC6032528 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature