Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease.

ABSTRACT: Parkinson's disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic neurons in the midbrain. Prior to diagnosis, there is a lengthy prodromal stage in which non-motor symptoms, including olfactory deficits (hyposmia), develop. There is limited information about non-motor impairments and there is a need for directed research into these early pathogenic cellular pathways that precede extensive dopaminergic death in the midbrain. The protein tau has been identified as a genetic risk factor in the development of sporadic PD. Tau knockout mice have been reported as an age-dependent model of PD, and this study has demonstrated that they develop motor deficits at 15-months-old. We have shown that at 7-month-old tau knockout mice presen

SUBMITTER: Beauchamp LC 

PROVIDER: S-EPMC6032546 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature