Genetic characterisation of molecular targets in carcinoma of unknown primary.

ABSTRACT:

Background

Carcinoma of unknown primary (CUP) is a metastatic epithelial malignancy in the absence of an identifiable primary tumour. Prognosis for patients with CUP is poor because treatment options are generally limited to broad spectrum chemotherapy. A shift towards personalised cancer management based on mutation profiling offers the possibility of new treatment paradigms. This study has explored whether actionable, oncogenic driver mutations are present in CUP that have potential to better inform treatment decisions.

Methods

Carcinoma of unknown primary cases (n = 21) were selected and DNA was isolated from formalin-fixed paraffin embedded sections prior to amplification and sequencing. Two distinct yet complementary targeted gene panels were used to assess variants in

SUBMITTER: Clynick B 

PROVIDER: S-EPMC6032776 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature