Immune regulatory cell infusion for graft-versus-host disease prevention and therapy.

ABSTRACT: Current approaches to prevent and treat graft-versus-host disease (GVHD) after stem cell transplantation rely principally on pharmacological immune suppression. Such approaches are limited by drug toxicity, nonspecific immune suppression, and a requirement for long-term therapy. Our increased understanding of the regulatory cells and molecular pathways involved in limiting pathogenic immune responses opens the opportunity for the use of these cell subsets to prevent and/or GVHD. The theoretical advantages of this approach is permanency of effect, potential for facilitating tissue repair, and induction of tolerance that obviates a need for ongoing drug therapy. To date, a number of potential cell subsets have been identified, including FoxP3⁺ regulatory T (Treg) and FoxP3^neg

SUBMITTER: Blazar BR 

PROVIDER: S-EPMC6032895 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature