Optogenetic Control of Voltage-Gated Calcium Channels.

ABSTRACT: Voltage-gated Ca²⁺ (Ca_V ) channels mediate Ca²⁺ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded Ca_V channel modulators, to enable photo-tunable modulation of Ca_V channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for Ca_V channels could find broad applications in interrogating a wide range of Ca_V -mediated physiological processes.

SUBMITTER: Ma G 

PROVIDER: S-EPMC6032918 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature