Analgesic effect of S (+)-flurbiprofen plaster in a rat model of knee arthritis: analysis of gait and synovial fluid prostaglandin E₂ levels.

ABSTRACT:

Objectives

We developed S (+)-flurbiprofen plaster (SFPP), a novel NSAID patch containing S (+)-flurbiprofen (SFP), a potent cyclooxygenase (COX) inhibitor. The purpose of this study was to assess efficacy of SFPP by analysing its effect on the gait disturbance and measuring the prostaglandin E₂ (PGE₂ ) production in synovial fluid in a rat model of knee arthritis.

Methods

Knee inflammation was induced in rats by intra-articular injection of a yeast suspension. Subsequently, an NSAID patch containing SFP, ketoprofen or loxoprofen was applied over the affected knee. Gait was assessed at 2, 4 and 6 h after application of the patch. The PGE₂ concentration in the synovial fluid was measured after the gait assessment.

Key findings

Applicati

SUBMITTER: Fukumoto A 

PROVIDER: S-EPMC6033094 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature