Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease.

ABSTRACT:

Aims

The aim of this study was to determine if elastin content in needle core native liver biopsies was predictive of clinical outcome in patients with chronic hepatitis C virus-related chronic liver disease.

Methods and results

Elastin contents in liver biopsies were determined by image analysis, technically validated in an independent centre, and correlated with outcome in patients with advanced (Ishak stage ≥5) chronic hepatitis C virus-related chronic liver disease. Elastin was robustly quantified in an operator-independent and laboratory-independent manner, with very strong correlation of elastin staining measured with two methods of image classification (r_s = 0.873, P < 0.00001). Elastin content (but not absolute scar content or Ishak stage) was predictive f

SUBMITTER: Kendall TJ 

PROVIDER: S-EPMC6033111 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature