Greater early postprandial suppression of endogenous glucose production and higher initial glucose disappearance is achieved with fast-acting insulin aspart compared with insulin aspart.

ABSTRACT:

Aim

To investigate the mechanisms behind the lower postprandial glucose (PPG) concentrations achieved with fast-acting insulin aspart (faster aspart) than with insulin aspart (IAsp).

Materials and methods

In a randomized, double-blind, crossover trial, 41 people with type 1 diabetes received identical subcutaneous single faster aspart and IAsp doses (individualized for each participant), together with a standardized mixed meal (including 75 g carbohydrate labelled with [1-¹³ C] glucose). PPG turnover was determined by the triple-tracer meal method using continuous, variable [6-³ H] glucose and [6,6-² H₂ ] glucose infusion.

Results

Insulin exposure within the first hour was 32% greater with faster aspart than with IAsp (treat

SUBMITTER: Basu A 

PROVIDER: S-EPMC6033168 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature