Gene Expression Profiling and Heterogeneity of Nonspecific Orbital Inflammation Affecting the Lacrimal Gland.

ABSTRACT:

Importance

Although a variety of well-characterized diseases, such as sarcoidosis and granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis are diagnosed as having nonspecific orbital inflammation (NSOI) on the basis of histology and systemic disease evaluation. The ability to further classify the disease in these patients should facilitate selection of effective therapies.

Objective

To test the a priori hypothesis that gene expression profiles would complement clinical and histopathologic evaluations in identifying well-characterized diseases and in subdividing NSOI into clinically relevant groups.

Design, setting, and participants

In this cohort study, gene expression levels in biopsy specimens of inflamed and control lacrima

SUBMITTER: Rosenbaum JT 

PROVIDER: S-EPMC6033262 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature