Utility of paraneoplastic antigens as biomarkers for surveillance and prediction of recurrence in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is frequently diagnosed at an advanced stage and 70% of patients experience recurrence months to years from initial diagnosis. The expression of paraneoplastic antigens can result in the occurrence of onconeural autoantibodies in ovarian cancer that may be associated with neurological disorders that are clinically manifested in patients before diagnosis of ovarian cancer. These paraneoplastic antigens can serve as excellent biomarkers not only for early detection but also for monitoring ovarian cancer recurrence.

Objective

To assess the immunoreactivity of our previous 3 biomarkers along with 3 paraneoplastic antigens, HARS, Ro52 and CDR2 for the evaluation of their sensitivity in predicting recurrence before the clinical relapse of the ovarian canc

SUBMITTER: Chatterjee M 

PROVIDER: S-EPMC6033268 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature