Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D₃ as host directed therapy.

ABSTRACT:

Background

We have previously shown that 8 weeks' treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D₃ (vitD₃) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum culture conversion and increased expression of cathelicidin LL-37 by immune cells in a randomized, placebo-controlled trial in adults with pulmonary tuberculosis (TB). In this study we further aimed to examine whether HDT with PBA and vitD₃ promoted clinically beneficial immunomodulation to improve treatment outcomes in TB patients.

Methods

Cytokine concentration was measured in supernatants of peripheral blood mononuclear cells (PBMC) from patients (n = 31/group). Endoplasmic reticulum stress-related genes (GADD34 and XBP1spl)

SUBMITTER: Rekha RS 

PROVIDER: S-EPMC6033279 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature