Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors.

ABSTRACT:

Background

Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or under-treated. In contrast to adjuvant endocrine therapy and chemotherapy, no diagnostic tests are in clinical use that can stratify patients for adjuvant radiotherapy. This study presents the development and validation of a targeted gene expression assay to predict the risk of ipsilateral breast tumor recurrence and response to adjuvant radiotherapy after breast-conserving surgery in primary breast cancer.

Methods

Fresh-frozen primary tumors from 336 patients radically (clear margins) operated on with breast-conserving surgery with or without radiotherapy were collected. Patients were split into a discovery cohort

SUBMITTER: Sjostrom M 

PROVIDER: S-EPMC6033283 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature