CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes.

ABSTRACT:

Background

In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan. Misregulated activation of primordial follicles leads to various ovarian diseases, such as premature ovarian insufficiency (POI). Although recent studies have revealed that several functional genes and pathways, such as phosphoinositide 3-kinase (PI3K) signaling, play roles in controlling the activation of primordial follicles, our understanding of the molecular networks regulating the activation progress is still incomplete.

Results

Here, we identify a new role for cell division cycle 42 (CDC42) in regulating the activation of primordial follicles in mice. Our results show that CDC42 expression increases in oocytes

SUBMITTER: Yan H 

PROVIDER: S-EPMC6033292 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature