Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells.

ABSTRACT: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders and causes cognitive impairment and memory deficits of the patients. The mechanism of AD is not well known, due to lack of human brain models. Recently, mini-brain tissues called organoids have been derived from human induced pluripotent stem cells (hiPSCs) for modeling human brain development and neurological diseases. Thus, the objective of this research is to model and characterize neural degeneration microenvironment using three-dimensional (3D) forebrain cortical organoids derived from hiPSCs and study the response to the drug treatment. It is hypothesized that the 3D forebrain organoids derived from hiPSCs with AD-associated genetic background may partially recapitulate the extracellular microenvironment i

SUBMITTER: Yan Y 

PROVIDER: S-EPMC6033307 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature