IBD Serology and Disease Outcomes in African Americans With Crohn's Disease.

ABSTRACT:

Backgrounds

Recent studies have identified the role of serologic markers in characterizing disease phenotype, location, complications, and severity among Northern Europeans (NE) with Crohn's disease (CD). However, very little is known about the role of serology in CD among African Americans (AA). Our study explored the relationship between serology and disease phenotype in AA with CD, while controlling for genetic ancestry.

Methods

AAs with CD were enrolled as participants through multicenter collaborative efforts. Serological levels of IgA anti-Saccharomyces cervisiae antibody (ASCA), IgG ASCA, E. coli outermembrane porin C, anti-CBir1, and ANCA were measured using enzyme-linked immunosorbent assays. Genotyping was performed using Illumina immunochip technology; an admixtur

SUBMITTER: Bertha M 

PROVIDER: S-EPMC6033326 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature