Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.

ABSTRACT: Neutrophils are known to possess both pro- and anti-tumor properties, a feature that could be related to the diversity and plasticity of these cells. Here we explored the hypothesis that under an appropriate environment and stimuli, neutrophils could induce an effective response against tumor cells. In a rat and mouse models, we show that a substantial amount of colon tumor associated-neutrophils (TAN) expressed the cytolytic enzyme granzyme B, which is absent in spleen or blood circulating neutrophils. This TAN population was also found into tumors of patients with colon cancer. Tumor neutrophil infiltration was correlated with an increase of chemokines known to attract neutrophils in both rat models and patients. These cells were involved in a Lipid A analog-mediated colon tumor regressi

SUBMITTER: Martin A 

PROVIDER: S-EPMC6033356 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature