Chemical exchange saturation transfer MRI serves as predictor of early progression in glioblastoma patients.

ABSTRACT:

Purpose

To prospectively investigate chemical exchange saturation transfer (CEST) MRI in glioblastoma patients as predictor of early tumor progression after first-line treatment.

Experimental design

Twenty previously untreated glioblastoma patients underwent CEST MRI employing a 7T whole-body scanner. Nuclear Overhauser effect (NOE) as well as amide proton transfer (APT) CEST signals were isolated using Lorentzian difference (LD) analysis and relaxation compensated by the apparent exchange-dependent relaxation rate (AREX) evaluation. Additionally, NOE-weighted asymmetric magnetic transfer ratio (MTRasym) and downfield-NOE-suppressed APT (dns-APT) were calculated. Patient response to consecutive treatment was determined according to the RANO criteria. Mean signal intensities

SUBMITTER: Regnery S 

PROVIDER: S-EPMC6033360 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature