Identification of novel susceptibility loci associated with hepatitis B surface antigen seroclearance in chronic hepatitis B.

ABSTRACT:

Background/aims

The seroclearance of hepatitis B virus (HBV) surface antigen (HBsAg) is regarded as a functional cure of chronic hepatitis B (CHB) although it occurs rarely. Recently, several genome-wide association studies (GWASs) revealed various genetic alterations related to the clinical course of HBV infection. However, all of these studies focused on the progression of HBV infection to chronicity and had limited application because of the heterogeneity of HBV genotypes. In the present study, we aimed to determine susceptibility genetic markers for seroclearance of HBsAg in CHB patients with a homogenous viral genotype.

Methods

One hundred patients with CHB who had experienced HBsAg seroclearance before 60 years of age and another 100 with CHB showing high serum levels

SUBMITTER: Kim TH 

PROVIDER: S-EPMC6033413 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature