B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of rhesus macaques.

ABSTRACT: Broadly neutralizing HIV-1 antibodies (bNAbs) isolated from infected subjects display protective potential in animal models. Their elicitation by immunization is thus highly desirable. The HIV-1 envelope glycoprotein (Env) is the sole viral target of bnAbs, but is also targeted by binding, non-neutralizing antibodies. Env-based immunogens tested so far in various animal species and humans have elicited binding and autologous neutralizing antibodies but not bNAbs (with a few notable exceptions). The underlying reasons for this are not well understood despite intensive efforts to characterize the binding specificities of the elicited antibodies; mostly by employing serologic methodologies and monoclonal antibody isolation and characterization. These approaches provide limited information on

SUBMITTER: Yacoob C 

PROVIDER: S-EPMC6033445 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature