Polygenic risk score of shorter telomere length and risk of depression and anxiety in women.

ABSTRACT: Prior studies have reported significant cross-sectional associations between depression or anxiety and shorter telomere lengths, but the temporality of associations is uncertain. Little is known regarding whether shorter telomere length is related to increased risk of developing depression or anxiety. In this study, using the genetic tool of polygenic risk score (PRS), we evaluated the association between genetic predisposition to shorter telomere length and the risks of lifetime clinically significant depression (defined by self-reported clinician/physician diagnosis, antidepressant use, and/or presence of severe depressive symptoms) and of clinically meaningful anxiety symptoms among 17,693 female participants of European ancestry. The weighted PRS of telomere lengths (TLs) combined the

SUBMITTER: Chang SC 

PROVIDER: S-EPMC6033543 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature