Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

ABSTRACT: Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes ¹ . Because OxPL are mostly the products of non-enzymatic lipid peroxidation, mechanisms to specifically neutralize them are unavailable and their roles in vivo are largely unknown. We previously cloned the IgM natural antibody E06, which binds to the phosphocholine headgroup of OxPL, and blocks the uptake of oxidized low-density lipoprotein (OxLDL) by macrophages and inhibits the proinflammatory properties of OxPL^2-4. Here, to determine the role of OxPL in vivo in the context of atherogenesis, we generated transgenic mice in the Ldlr^-/- background that expressed a single-chain variable frag

SUBMITTER: Que X 

PROVIDER: S-EPMC6033669 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature