Direct comparison of ten quantitative fecal immunochemical tests for hemoglobin stability in colorectal cancer screening.

ABSTRACT:

Objectives

To systematically investigate and directly compare, for the first time, the sample stability of a large number of quantitative fecal immunochemical tests (FITs) at different storage conditions.

Methods

Stool samples were obtained from participants of the German screening colonoscopy program between 2005 and 2010. After an initial FIT-based hemoglobin (Hb) measurement, stool samples were kept frozen at -80 °C until analysis. Twenty randomly selected participants with initial measurements ranging from 10 to 100 μg Hb/g feces were included. Ten quantitative FITs were investigated in parallel. A defined stool amount was extracted using each manufacturer's brand-specific fecal sampling device and stored at 5 °C, 20 °C, and 35 °C, respectively. After 1, 4, 5, and 7 days

SUBMITTER: Gies A 

PROVIDER: S-EPMC6033915 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature