Ontology highlight
ABSTRACT:
SUBMITTER: Nigita G
PROVIDER: S-EPMC6033928 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20180705 1
RNA editing in microRNAs has been recently proposed as a novel biomarker in cancer. Here, we investigated RNA editing by leveraging small-RNA sequencing data from 87 NSCLC (Non-Small Cell Lung Cancer) samples paired with normal lung tissues from The Cancer Genome Atlas (TCGA) combined with 26 plasma-derived exosome samples from an independent cohort. Using both the editing levels and microRNA editing expression, we detected deregulated microRNA editing events between NSCLC tumor and normal tissu ...[more]