Pre-Activation of Toll-Like Receptor 2 Enhances CD8⁺ T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models.

ABSTRACT: Toll-like receptors (TLRs) play a crucial role in activation of innate immunity, which is essential for inducing effective adaptive immune responses. Our previous studies have shown that toll-like receptor 2 (TLR2) is required to induce effective virus-specific T-cell responses against hepatitis B virus (HBV) in vivo. However, the contribution of TLR2 activation to adaptive immunity and HBV clearance remains to be clarified. In this study, we explored the hydrodynamic injection (HI) mouse models for HBV infection and examined how the TLR2 agonist Pam3CSK (P3C) influences HBV control and modulates HBV-specific T-cell response if applied in vivo. We found that TLR2 activation by P3C injection leads to the rapid but transient production of serum proinflammatory factors interleuk

SUBMITTER: Lin Y 

PROVIDER: S-EPMC6033958 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature