Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism.

ABSTRACT:

Objective

N-acylethanolamines play different roles in energy balance; anandamide (AEA) stimulates energy intake and storage, N-palmitoylethanolamide (PEA) counters inflammation, and N-oleoylethanolamide (OEA) mediates anorectic signals and lipid oxidation. Inconsistencies in the association of plasma N-acylethanolamines with human obesity and cardiometabolic risk have emerged among previous studies, possibly caused by heterogeneous cohorts and designs, and by unstandardized N-acylethanolamine measurements. We aimed to characterize changes in the plasma profile, including N-acylethanolamine levels and ratios associated with obesity, menopause in women, and ageing in men, and to define the significance of such a profile as a biomarker for metabolic imbalance.

Methods

Adult, dr

SUBMITTER: Fanelli F 

PROVIDER: S-EPMC6034062 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature